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Best pain relievers - August 2025

Last Updated - August 28, 2025

1
Best Choice
11% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Advil
11% Off

Advil Dual Action Coated Caplets with Acetaminophen, 250 Mg Ibuprofen and 500 Mg Acetaminophen Per Dose (2 Dose Equivalent) for 8 Hour Pain Relief- 216 Count

Advil

$25.49

$28.65
(11% Off)

More Details
Main highlights
- The first FDA approved pain relief medication with a combination of acetaminophen and ibuprofen
- Pain pills that relieve pain in two ways, providing powerful relief with a lower maximum daily dose of each medication
- Pain medicine that provides relief for 8 hours - the perfect addition to your college dorm room essentials
- Multi symptom pain medication that provides headache, toothache, menstrual cramp, muscle pain and lower back pain relief while also relieving minor aches and pains associated with arthritis
- HSA and FSA eligible product
- Advil Dual Action coated tablets relieve pain with ibuprofen to target pain at the source and acetaminophen to block pain signals, and by 2022, new packaging will feature 20% less plastic to keep nearly 500,000 pounds of plastic out of landfills
$25.49
$28.65 (11% Off)
2

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Aleve

Aleve Back & Muscle Pain Relief Naproxen Sodium Tablets, Pain Reliever & Fever Reducer, Medicine for Body , 250 Count

Aleve

$24.96

More Details
Main highlights
- Up to 12-Hours of Uninterrupted Pain Relief: Aleve Back & Muscle Pain Relief Tablets provide long-lasting back pain and muscle pain relief
- Targeted Pain Relief: Every tablet is made with 220 mg of naproxen sodium to help you take on muscle pain and provide back pain relief
- Fever Reducer: Temporarily reduces fever for adults and children aged 12 and up
- Effective Pain Reliever: In a study, proven as effective and longer lasting than a common Rx pain reliever. Ask a doctor if Aleve is right for you
- Comes in small, easy-to-swallow tablets; use as directed
$24.96
3
Best Value
24% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol
24% Off

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

Tylenol

$12.47

$16.59
(24% Off)

More Details
Main highlights
- With 500 mg of acetaminophen per gelcap, this extra strength oral pain reliever is fast-acting and can be used by adults and children who are 12 years and older
- Use as a fever reducer and to relieve minor aches and pains including headache, backache, toothache, menstrual and premenstrual cramps, minor pain of arthritis, joint and muscle pain, and pain caused by the common cold and flu
- Experience relief of minor aches and pains with Tylenol, the #1 doctor recommended brand for pain relief and fever reduction
- Each pain reliever gelcap features laser-drilled holes to quickly release pain medicine and contains 500 mg of acetaminophen for fast, effective extra strength pain relief that works at the speed of life, while being gentle on the stomach
- 100-count Tylenol Extra Strength Rapid Release Gels pain relief medicine with acetaminophen work fast to temporarily relieve minor aches and pains, headaches, and help reduce fever
$12.47
$16.59 (24% Off)
4
20% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Motrin
20% Off

Motrin Dual Action with Tylenol, Ibuprofen & Acetaminophen Fast-Acting Dual Action Pain Reliever for Minor Aches & Pains, Ibuprofen (NSAID) 125 mg & Acetaminophen 250 mg, 120 ct

Motrin

$12.74

$15.97
(20% Off)

More Details
Main highlights
- Pain Relief for Adults: Motrin Dual Action with Tylenol pain relief medicine is intended for adults and children 12 years of age and older with minor aches and pains; take two pain relief tablets every 8 hours while symptoms persist
- Muscle Pain Relief: Use this 2-in-1 pain reliever medicine to temporarily relieve minor aches and pains due to headache, toothache, and muscle aches; Motrin Dual Action with Tylenol works for period cramps pain relief and is an arthritis pain reliever
- Dual Action Pain Reliever: One 120 count bottle of Motrin Dual Action with Tylenol, dual action ibuprofen (NSAID) and acetaminophen, pain reliever with two medicines for minor aches and pains
- Contains Acetaminophen: Motrin Dual Action with Tylenol contains acetaminophen; severe liver damage may occur if you take with other drugs containing acetaminophen
- Acetaminophen and Ibuprofen: The dual action Motrin with Tylenol pain relief tablets each contain 250 mg acetaminophen plus 125 mg ibuprofen (nonsteroidal anti-inflammatory drug) to temporarily relieve minor aches and pains
$12.74
$15.97 (20% Off)
5
10% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basic Care
10% Off

Amazon Basic Care Naproxen Sodium Tablets 220 mg, Pain Reliever/Fever Reducer (NSAID), Muscular Aches, Backache, Headache, Toothache, Minor Arthritis Pain Relief & More, 300 Count (Packaging may vary)

Amazon Basic Care

$12.80

$14.24
(10% Off)

More Details
Main highlights
- STRENGTH TO LAST 12 HOURS: Pain reliever and fever reduction for up to 12 hours so you can get through the day
- CAPSULE-SHAPED TABLETS: This 12 hour pain reliever and fever reducer comes in a capsule-shaped tablet; this product is gluten free
- ALL DAY RELIEF: Amazon Basic Care Naproxen Sodium Tablets 220 mg is a pain reliever and fever reducer for adults and children age 12 years and over
- ACTIVE INGREDIENT: This pain reliever and fever reducer contains naproxen sodium 220 mg, a nonsteroidal anti-inflammatory drug (NSAID); compare to the active ingredient in Aleve Caplets
- ACHES AND PAINS: Temporarily relieves minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache, toothache and the common cold; also temporarily reduces fever
$12.80
$14.24 (10% Off)

Best pain relievers - August 2025

Advil Dual Action Coated Caplets with Acetaminophen, 250 Mg Ibuprofen and 500 Mg Acetaminophen Per Dose (2 Dose Equivalent) for 8 Hour Pain Relief- 216 Count

Aleve Back & Muscle Pain Relief Naproxen Sodium Tablets, Pain Reliever & Fever Reducer, Medicine for Body , 250 Count

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

Motrin Dual Action with Tylenol, Ibuprofen & Acetaminophen Fast-Acting Dual Action Pain Reliever for Minor Aches & Pains, Ibuprofen (NSAID) 125 mg & Acetaminophen 250 mg, 120 ct

Amazon Basic Care Naproxen Sodium Tablets 220 mg, Pain Reliever/Fever Reducer (NSAID), Muscular Aches, Backache, Headache, Toothache, Minor Arthritis Pain Relief & More, 300 Count (Packaging may vary)

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